Methandrostenolone does react strongly with the androgen receptor but still exerts its effects through the androgen receptor in vivo. These include dramatic increases in protein synthesis, glycogenolysis, and muscle strength over a short space of time. In high doses (30 mg or more per day), side effects such as gynecomastia, high blood pressure, acne and male pattern baldness may begin to occur. The drug causes severe masculinising effects in women even at low doses. In addition, it is metabolized into methylestradiol effects will appear over time in men. Many users will combat the by aromatase. This means that without the administration of aromatase inhibitors such as anastrozole or aminoglutethimide, estrogenicestrogenic side effects with Nolvadex or Clomid.